Early Anti-inflammatory Topical Acne Therapy May Improve Outcomes and Reduce Bacterial Resistance

stood, although primary contributory factors have been identified. Propionibacterium acnes, a commensal organism that plays an active role in acne vulgaris, thrives in the presence of excess sebum and has been shown to mediate inflammatory processes at the site of the sebaceous follicle, contributing to the formation of free radical species and generating pro-inflammatory cytokines. Coupled with faulty keratinization, excess sebum production and P. acnes colonization contribute to the formation of microcomedones, ultimately leading to development of the comedones, papules, pustules, and cysts characteristic of acne. The presence of active acne lesions impacts the individual’s appearance, has negative effects on psycho-social function, and can be associated with potential physical discomfort. Scarring following acne is a significant risk and has been identified as the most devastating sequelum to the patient. Acne is a chronic condition, similar in its impact and duration to atopic dermatitis. Patients may be subEarly Anti-inflammatory Topical Acne Therapy May Improve Outcomes and Reduce Bacterial Resistance